I've worked in lupus research and one of the things rheumatologists have told me is they see it frequently triggered by the most stressful events in people's lives. So a divorce, eviction, moving, death of a parent or child.
Fortunately great steps have been taken with diagnosis and awareness (it used to not only be hard to find but very stigmatized, lumped in with psycho-somatic disorders like fibromyalgia, long COVID and chronic lyme).
I've worked in lupus research and one of the things rheumatologists have told me is they see it frequently triggered by the most stressful events in people's lives. So a divorce, eviction, moving, death of a parent or child.
https://hsph.harvard.edu/news/stress-trauma-lupus/
Fortunately great steps have been taken with diagnosis and awareness (it used to not only be hard to find but very stigmatized, lumped in with psycho-somatic disorders like fibromyalgia, long COVID and chronic lyme).
Personally I think the T-cell immune balance research is promising: https://www.prnewswire.com/news-releases/lra-awards-2025-lup...
as well as PARP inhibitors for precision medicine https://clinicaltrials.gov/study/NCT05966480
Car-T for lupus thus far has been a nothingburger (Cabaletta Bio, Nkarta, Kyverna, etc).