Stomach paralysis is apparently a known side effect [1]. There are also lots of anecdotes about lesser (but still foul) digestive surprises that are too unpleasant for me to bother elaborating on here.
I was on my thiccboi swag for the latter half of last year and am presently working it off by rebuilding my fitness base with kettlebells and cardio. I'd rather do this than GLP-1s not because I'm some sort of iron-willed badass so much as I'm simply distrustful of anything that messes with one's metabolism so severely. While these drugs are useful for the morbidly obese and diabetics I simply can't imagine how or why anybody would go on them for aesthetic or off-label purposes.
>Stomach paralysis is apparently a known side effect [1]. There are also lots of anecdotes about lesser (but still foul) digestive surprises that are too unpleasant for me to bother elaborating on here.
These are real, but they're also not permanent, and are why you start on a low dose to evaluate how your body reacts to the medication. My spouse is a long time GLP-1 user (coming up on four years now) and had mild (or more) bouts of several of these digestive related systems.
However, within six months these had greatly diminished. And by the one year mark, even at the highest dose, they were essentially gone and have remained a non-issue since.
You should certainly be mindful of side effects, and follow the recommended dosage scale up, which should be monitored by your doctor.
>I was on my thiccboi swag for the latter half of last year and am presently working it off by rebuilding my fitness base with kettlebells and cardio. I'd rather do this than GLP-1s not because I'm some sort of iron-willed badass so much as I'm simply distrustful of anything that messes with one's metabolism so severely. While these drugs are useful for the morbidly obese and diabetics I simply can't imagine how or why anybody would go on them for aesthetic or off-label purposes.
I do think folks with obesity fall into one of two camps (or somewhere on a spectrum between): those that are in that place because they don't put in any effort, eat whatever they want, don't workout, and so on.
And then there are folks like my spouse. They were able to lose weight in the past, but only through continued suffering. To be "just" overweight, they needed to be working out constantly and in a state of always feeling hungry. They never reached an equilibrium where it wasn't agony to maintain that weight, and after months/years would always rebound.
For them, a GLP-1 was the only thing that ever quieted the food noise. They workout constantly still and are in the best shape of their life. It wasn't entirely the GLP-1, but that gave them the tool to quiet the noise and get to a state where fitness could be fun/sustainable, and now they're killing it.
So, the TL;DR is that some people need this tool, and it's not necessarily an either/or. It can be one part in a series of positive changes that lead to better health and well-being.
GLP-1 drugs carry a small risk of gastroparesis, which can be severe in some patients. I wouldn't recommend avoiding using them due to that risk if medically indicated but patients should be aware.
To be fair, we have seen some long term effects from antibiotic use. Especially with regards to gut biomes. However, the long term effect of not using them is oftentimes death or permanent disability. Don't see nearly as many amputations from infected scratches these days thankfully.
Or like Vitamin C. There aren’t side effects to fixing a vitamin deficiency. This increasingly, to me, looks like that. (There are absolutely bad effects from overdoing it.)
Vitamin C is a water soluble vitamin. It’s pretty damn hard to get Vitamin C toxicity from overconsumption. It’s not really something to worry about. This is true for all the water soluble vitamins.
This isn’t true for the fat soluble vitamins. Those are Vitamin A, Vitamin E, Vitamin K and Vitamin D.
You can overdose and get toxicity if you consume too much of these. For Vitamin D you can’t overdose from what your body generates from the skin but you can from the oral forms.
Stomach paralysis is apparently a known side effect [1]. There are also lots of anecdotes about lesser (but still foul) digestive surprises that are too unpleasant for me to bother elaborating on here.
I was on my thiccboi swag for the latter half of last year and am presently working it off by rebuilding my fitness base with kettlebells and cardio. I'd rather do this than GLP-1s not because I'm some sort of iron-willed badass so much as I'm simply distrustful of anything that messes with one's metabolism so severely. While these drugs are useful for the morbidly obese and diabetics I simply can't imagine how or why anybody would go on them for aesthetic or off-label purposes.
[1] https://www.webmd.com/obesity/ozempic-and-stomach-paralysis
>Stomach paralysis is apparently a known side effect [1]. There are also lots of anecdotes about lesser (but still foul) digestive surprises that are too unpleasant for me to bother elaborating on here.
These are real, but they're also not permanent, and are why you start on a low dose to evaluate how your body reacts to the medication. My spouse is a long time GLP-1 user (coming up on four years now) and had mild (or more) bouts of several of these digestive related systems.
However, within six months these had greatly diminished. And by the one year mark, even at the highest dose, they were essentially gone and have remained a non-issue since.
You should certainly be mindful of side effects, and follow the recommended dosage scale up, which should be monitored by your doctor.
>I was on my thiccboi swag for the latter half of last year and am presently working it off by rebuilding my fitness base with kettlebells and cardio. I'd rather do this than GLP-1s not because I'm some sort of iron-willed badass so much as I'm simply distrustful of anything that messes with one's metabolism so severely. While these drugs are useful for the morbidly obese and diabetics I simply can't imagine how or why anybody would go on them for aesthetic or off-label purposes.
I do think folks with obesity fall into one of two camps (or somewhere on a spectrum between): those that are in that place because they don't put in any effort, eat whatever they want, don't workout, and so on.
And then there are folks like my spouse. They were able to lose weight in the past, but only through continued suffering. To be "just" overweight, they needed to be working out constantly and in a state of always feeling hungry. They never reached an equilibrium where it wasn't agony to maintain that weight, and after months/years would always rebound.
For them, a GLP-1 was the only thing that ever quieted the food noise. They workout constantly still and are in the best shape of their life. It wasn't entirely the GLP-1, but that gave them the tool to quiet the noise and get to a state where fitness could be fun/sustainable, and now they're killing it.
So, the TL;DR is that some people need this tool, and it's not necessarily an either/or. It can be one part in a series of positive changes that lead to better health and well-being.
GLP-1 drugs carry a small risk of gastroparesis, which can be severe in some patients. I wouldn't recommend avoiding using them due to that risk if medically indicated but patients should be aware.
https://www.centraloregondaily.com/news/consumer/glp-1-weigh...
Diabetes can cause gastroparesis too. I assume a large number of folks taking these drugs are diabetic.
several years ago that might be true
in 2026 its... to quote South Park... "the rich get Ozympic, the poor get Body Positivity"
To be fair, we have seen some long term effects from antibiotic use. Especially with regards to gut biomes. However, the long term effect of not using them is oftentimes death or permanent disability. Don't see nearly as many amputations from infected scratches these days thankfully.
Or like Vitamin C. There aren’t side effects to fixing a vitamin deficiency. This increasingly, to me, looks like that. (There are absolutely bad effects from overdoing it.)
Hey just want to add something.
Vitamin C is a water soluble vitamin. It’s pretty damn hard to get Vitamin C toxicity from overconsumption. It’s not really something to worry about. This is true for all the water soluble vitamins.
This isn’t true for the fat soluble vitamins. Those are Vitamin A, Vitamin E, Vitamin K and Vitamin D.
You can overdose and get toxicity if you consume too much of these. For Vitamin D you can’t overdose from what your body generates from the skin but you can from the oral forms.
My understanding is it's virtually impossible to overdose vitamin K (without injecting it anyway), and pretty difficult to do so with Vitamin D.